TailwindCSS is a "utility-first CSS framework". I know CSS inside out and was skeptical about Tailwind at first. In general, there seems to be a great divide between developers when it comes to this tool. Those who have used it in practice swear by it, so I gave Tailwind a chance. Tailwind Labs has a number of great introductory videos1 to get you started.
After over a year of using Tailwind for various personal web projects including this website, I am not looking back. Tailwind offers sane defaults and allows all the customization you need. I'm not constantly switching between CSS files and HTML views. Especially during the initial development or prototyping, TailwindCSS makes it dead-easy to create pleasing-looking results with very little effort.